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3 open PhD student positions (m/f/d) (TV-L 13 65%, 3 years)

General Information

The DFG-funded International Research Training Group GRK2662 "Charging into the future: understanding the interaction of polyelectrolytes with biosystems", aims for a better understanding of the molecular interactions between polyelectrolytes such as DNA, proteins or heparin with complex biological systems. Key to this is a close collaboration between researchers at Freie Universität Berlin (Germany), McGill University, Montréal, and the University of British Columbia, Vancouver (Canada), who share complementary expertise.

The International Research Training Group GRK2662 offers
- positions with a duration of three years and the opportunity for writing a doctoral thesis,
- a structured scientific training in an international research environment, including participation in a wide range of research-specific and career-development training events,
- integration into an interdisciplinary international research network,
- the opportunity for research stays in the laboratories of the Canadian partner institutions.

Requirements
Completed scientific University degree in chemistry, biochemistry, biophysics or related subjects.

Application

We look forward to receiving your application, which should include the following documents:
• A one-page motivation letter with details of previous research experience and future goals
• Your curriculum vitae (with list of publications, if applicable),
• Evidence of your academic achievements including copies of your Bachelor's and Master's or Diploma degrees,
• At least two letters of support.

We reserve the right to reject incomplete applications without giving further reasons.

Application deadline 24.10.2022

For further information, please contact Mrs. Anna Wolf (bewerbung@grk2662.de / +493083868438).


Position 1 (Project A2 - reference code: grk2662_Praedoc_A2)

Glycosaminoglycans and their interaction with amyloid-forming peptides

In project A2, glycosaminoglycans (GAGs) and their interaction with amyloid-forming peptides are investigated. In this context, GAG binding to amyloid-forming model peptides and their assemblies will be probed in the project of Prof. Dr. Kevin Pagel. Task within this project include heparinase digestion, purification and modification of GAGs. For further project information, please visit www.grk2662.de.

The position serves the own scientific Qualification.

Desirable:
• High motivation to conduct independent scientific work
• Very good English skills both written and spoken
• Good communication skills and appreciation for cooperative team work
• Experience with analytical and preparative Liquid Chromatography
• Experience with Mass Spectrometry and related techniques
• Basic knowledge in glycobiology

Click here for:

German job posting

English job posting


Position 2 (Project A3 - reference code: grk2662_Praedoc_A3)

Elucidating structural implications of polyelectrolyte protein interactions

This project (A3), hosted in the research group of Thomas Risse at FU-Berlin, aims at elucidating the structural implications of polyelectrolyte protein interactions on protein structure using spectroscopy particularly focusing on EPR and IR spectroscopy. The focus will be on two systems: firstly, the interaction of HMGB1 (High-Mobility-Group-Protein B1) with polysulfates will be studied in cooperation with the group of Jens Dernedde, Charite Berlin. Secondly, the interaction of the amyloid forming peptide A-beta with such polyelectrolytes will be elucidated in collaboration with the group of Gerd Multhaup, McGill University, Montréal (Canada). It is expected that the successful applicant is doing part of the experimental work in the partner group in Canada. For further project information, please visit www.grk2662.de.

The position serves the own scientific Qualification.

Desirable:
• High motivation to conduct independent scientific work
• Very good English skills both written and spoken
• Good communication skills and appreciation for cooperative team work
• Hands on experience in protein biochemistry
• Hands on in spectroscopy

Click here for:

German job posting

English job posting


Position 3 (Project B1 - reference code: grk2662_Praedoc_B1)

Dendritic polyelectrolytes to promote enhanced neuronal biocompatibility

In project B1, dendritic polyelectrolytes are synthesized and their ability to promote enhanced neuronal biocompatibility is investigated. The project performed in the group of Dr. Stephan Block will use atomic force microscopy (AFM), confocal laser scanning microscopy (CLSM), and total internal reflection fluorescence microscopy (TIRF) to probe the interaction of the synthesized polyelectrolytes with proteins and neuronal cells. For further project information, please visit www.grk2662.de.

The position serves the own scientific Qualification.

Desirable:

• Experience in the application of atomic force microscopy or optical microscopy
• Experience in using MatLab or related software for analyzing large datasets
• Experience in analyzing force spectroscopic data or in quantitative image analysis
• High motivation to conduct independent scientific work
• Very good English skills both written and spoken
• Good communication skills and appreciation for cooperative team work

Click here for:

German job posting

English job posting